Refractory myasthenia gravis
Objective: To describe a patient with intractable myasthenia gravis (MG) who was treated with a matched sibling peripheral blood stem cell transplantation. Design: Case report. Patient A 17-year-old boy with MG diagnosed at 11 months of age who was previously treated with pyridostigmine, intravenous immunoglobulin, corticosteroids, thymectomies, azathioprine, …INTRODUCTION Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fluctuating motor weakness involving ocular, bulbar, limb, and/or respiratory muscles.
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Nov 9, 2021 · All the above-mentioned favorable outcomes of rituximab in refractory myasthenia gravis patients have widened the options for treatment of refractory myasthenia gravis; they have also demonstrated that RTX could improve patients' quality of life by decreasing dose-related adverse effects and sustaining remission [10,12-17]. Even though RMG ... Myasthenia Gravis (MG) is a chronic autoimmune disease (AID) with a prevalence of 1–2 per 10.000 [1]. The clinical hallmark is fluctuating weakness of striated muscles with antibodies directly affecting the neuromuscular junction. In approximately 85% of patients, the initial presenting symptoms are asymmetric ptosis and/or diplopia. Approximately 80% of initially ocular MG …Objective To update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature. Methods In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was …Approximately 15% of patients with generalized myasthenia gravis (gMG) do not respond to standard immunosuppressive therapies (ISTs), or require intravenous immunoglobulin (IVIg) or plasma exchange (PLEX) to manage their symptoms. 1 –3 For these patients with treatment-refractory myasthenia gravis (MG), disease control is impaired; a study in ...The humanized monoclonal antibody eculizumab (Soliris ®) is a complement inhibitor indicated for use in anti-acetylcholine receptor (AChR) antibody-positive adults with generalized myasthenia gravis (gMG) in the USA, refractory gMG in the EU, or gMG with symptoms that are difficult to control with high-dose IVIg therapy or PLEX in Japan.Tacrolimus in refractory patients with myasthenia gravis: coadministration and tapering of oral prednisolone J Clin Neurosci , 13 ( 1 ) ( 2006 ) , pp. 39 - 44 View PDF View article View in Scopus Google ScholarJul 22, 2020 · Objective. To assess whether eculizumab, a terminal complement inhibitor, improves patient‐ and physician‐reported outcomes (evaluated using the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale, respectively) in patients with refractory anti‐acetylcholine receptor antibody‐positive generalized myasthenia gravis across four domains ... Introduction Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable muscle weakness. MG is specifically thought to be an antibody-mediated disease. In approximately 85 percent of patients, antibodies are detected against the nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction [ 1 - 3 ].In the past 5 years there has been a surge in the development of targeted molecular therapy as an alternative to traditional myasthenia gravis treatment. Three promising biological drugs are now used for or expected to be safe and efficacious in the management of patients with refractory myasthenia gravis. The first, rituximab, is a chimeric ... Vissing J, O’Brien F, Wang JJ, et al. Correlation between myasthenia gravis-activities of daily living (MG-ADL) and quantitative myasthenia gravis (QMG) assessments of anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis in the phase 3 REGAIN study.Abstract. Myasthenia gravis (MG), a prototype autoimmune neurological disease, had its therapy centred on corticosteroids, non-steroidal broad-spectrum immunotherapy and cholinesterase inhibitors for several decades. Treatment-refractory MG and long-term toxicities of the medications have been major concerns with the conventional therapies.Objective To update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature. Methods In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was …Myasthenia gravis (MG) is a long-term neuromuscular junction disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. Onset can be sudden. Those affected often have a large thymus or develop a …Understanding the burden of refractory myasthenia gravis Abstract. Myasthenia gravis (MG) is an autoantibody-mediated disease that compromises the acetylcholine receptors or... Introduction. Myasthenia gravis (MG) is a rare, antibody-mediated autoimmune disease of the neuromuscular junction,... ...The Article Processing Charge was funded by the Myasthenia Gravis Foundation of America. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible toClinical characteristics of refractory myasthenia gravis patients. 2013 Jun 13;86 (2):255-60. Jonathan M Goldstein. PMC3670444. A subset of myasthenia gravis (MG) patients is refractory to standard therapies. Identifying the characteristics of this population is essential as newer treatment strategies emerge that may be more effective …Clinical characteristics of refractory myasthenia gravis patients. 2013 Jun 13;86 (2):255-60. Jonathan M Goldstein. PMC3670444. A subset of myasthenia gravis (MG) patients is refractory to standard therapies. Identifying the characteristics of this population is essential as newer treatment strategies emerge that may be more effective …Key Points. Question Does the response to rituximab differ between patients with new-onset vs refractory generalized myasthenia gravis, and how does rituximab compare with conventional immunotherapy in these patients?. Findings In this cohort study of 72 patients exposed to rituximab early or later in the myasthenia gravis disease course as well as …Methods: This study was a randomized, double-blind, placebo-controlled, crossover trial involving 14 patients with severe, refractory generalized MG (gMG). Results: Six of 7 patients treated with eculizumab for 16 weeks (86%) achieved the primary endpoint of a 3-point reduction in the quantitative myasthenia gravis (QMG) score. Examining both ...Refractory myasthenia gravis identifies the group of patients that have inadequate symptom control and persistent muscle weakness and fatigability despite the use of multiple immune modulatory therapies. This manuscript highlights what is currently known about refractory myasthenia gravis and underlines major knowledge gaps, drawing attention to the …Myasthenia Gravis (MG) is a rare autoimmune disorder that targets the neuromuscular junction (NMJ). It is caused by B-cell activation with subsequent production of autoantibodies targeting different proteins of the postsynaptic endplate. About 80–90% of patients have antibodies directed against the nicotinic acetylcholine receptor (AChR ...Introduction. Acquired myasthenia gravis (MG) is caused by an autoreactive humoral response against the postsynaptic end plate of the neuromuscular junction, with a prevalence of 24.8 to 27.8 per 100 000 in a Swedish nationwide study. 1,2 Myasthenia gravis can be stratified based on age, autoantibodies, presence of thymoma, and clinical symptoms, all of which may affect treatment response. 3,4 ...Abstract. Objective: To describe the clinical chDefining ‘treatment-refractory myasthenia g The term myasthenia gravis (MG) is derived from the Greek terms my, asthenia, and gravis, which mean muscle, weakness, and severe, respectively. ... Zebardast N, Goldstein JM. Response of patients with refractory myasthenia gravis to rituximab: A retrospective study. Therapeutic Advances in Neurological Disorders. 2011; …Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable muscle weakness. MG is specifically thought to be an antibody-mediated disease. MG can be treated, but a subset of patients remains refractory to conventional therapies, leading to refractory generalized myasthenia gravis (gMG). Background: This retrospective cohort study was conducted to eva Background: In the phase III eculizumab for refractory generalized myasthenia gravis REGAIN study [ClinicalTrials.gov identifier: NCT01997229] and its open-label extension (OLE) [ClinicalTrials.gov identifier: NCT02301624], patients with treatment-refractory antiacetylcholine receptor antibody-positive generalized …Gotterer L, Li Y. Maintenance immunosuppression in myasthenia gravis. J Neurol Sci. 2016 Oct 15;369:294–302 [Web of Science ®], [Google Scholar] Schneider-Gold C, Hagenacker T, Melzer N, et al. Understanding the burden of refractory myasthenia gravis. Ther Adv Neurol Disord. 2019 Feb;12:1756286419832242. Myasthenia gravis (MG) is an autoimmune neuromuscula
Methods: Adults (aged 18-64 years, all diagnosed ≥2 years previously) were included if enrolled in the Myasthenia Gravis Foundation of America Patient Registry during July 2013 to February 2018. Results: Seventy-six patients (9.2%) had refractory and 749 (90.8%) had nonrefractory disease; demographic data did not differ between groups.Myasthenia gravis (MG) is a chronic rare autoimmune disease characterized by severe muscle weakness and caused by the inhibition of neuromuscular transmission due to the binding of autoantibodies at the neuromuscular junction and subsequent complement-mediated destruction of the end-plate region. The prevalence of MG has been estimated as ...In the past 5 years there has been a surge in the development of targeted molecular therapy as an alternative to traditional myasthenia gravis treatment. Three promising biological drugs are now used for or expected to be safe and efficacious in the management of patients with refractory myasthenia gravis. The first, rituximab, is a chimeric ...Objective: To describe a patient with intractable myasthenia gravis (MG) who was treated with a matched sibling peripheral blood stem cell transplantation. Design: Case report. Patient A 17-year-old boy with MG diagnosed at 11 months of age who was previously treated with pyridostigmine, intravenous immunoglobulin, corticosteroids, thymectomies, azathioprine, …Jan 19, 2021 · Objective To update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature. Methods In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened. The RAND/UCLA appropriateness method was used to develop ...
Introduction: Approximately 10-20% of patients WITH myasthenia gravis (MG) are refractory to conventional immunotherapies. The purpose of this study was to conduct a systematic review and meta-analysis to explore the optimal therapies for refractory MG. Method: Correlative studies were …Myasthenia gravis (MG) is an autoantibody-mediated neuromuscular junction disorder involving the acetylcholine receptors on the motor endplate. The safety and response to high-dose chemotherapy (HDIT) and autologous hematopoietic cell transplantation (HCT) were assessed in a patient with severe refractory MG.…
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Introduction. Myasthenia gravis (MG) is an antibody-mediated autoimmune disease characterized by fatigable muscle weakness. It is the most frequent neuromuscular junction disorder, with an overall prevalence rate of 15-179 per million individuals [].Eighty percent of MG patients have antibody production against the nicotinic acetylcholine receptor (AchR) in the …Understanding the burden of refractory myasthenia gravis Abstract. Myasthenia gravis (MG) is an autoantibody-mediated disease that compromises the acetylcholine receptors or... Introduction. Myasthenia gravis (MG) is a rare, antibody-mediated autoimmune disease of the neuromuscular junction,... ...
A series of patients with refractory myasthenia gravis. 2020 Nov 7;S0213-4853 (20)30293-0. doi: 10.1016/j.nrl.2020.08.016. Online ahead of print. Advances in the treatment of myasthenia gravis (MG) have improved quality of life and prognosis for the majority of patients. However, 10%-20% of patients present refractory MG, with frequent relapses ... Introduction: This study assessed the clinical burden of refractory myasthenia gravis (MG), relative to nonrefractory MG. Methods: Rates of myasthenic crises, exacerbations, inpatient hospitalizations, and emergency room (ER) visits over a 1-year period were measured for 403 refractory, 3,811 nonrefractory, and 403 non-MG control patients from …Side effects, which usually are mild, can include chills, dizziness, headaches and fluid retention. Monoclonal antibody. Rituximab (Rituxan) and eculizumab (Soliris) are medicines given by vein for myasthenia gravis. These medicines are usually used when other treatments don't work. They can have serious side effects.
Myasthenia gravis is an autoimmune disease associated with seve Apr 9, 2019 · Myasthenia gravis is an autoimmune disease mediated by organ-specific antibody. These antibodies are present at neuromuscular junction (NMJ) and directed against nicotinic acetylcholine receptor (AChR) on the postsynaptic muscle membrane in 80–90% of patients. In 3–7%, the autoantibodies are directed against another NMJ protein, muscle ... Introduction. Myasthenia gravis (MG) is an autoimmune condition of the neuromuscular junction, characterized by weak and fatigable skeletal muscles.1 Approximately 80–85% of MG patients respond favorably to available immunosuppressive therapies, which include steroids, azathioprine (Az), mycophenolate mofetil (MM), cyclosporine (Cy), intravenous immunoglobulin (IVIG), plasma exchange (PLEX ... Introduction: Labor-market participation is poteAbstract. Myasthenia gravis (MG), a prototype autoimmune neurolo Dec 11, 2019 · Myasthenia gravis is an autoimmune disease of the neuromuscular junction with a prevalence of around 16 per 100,000 [ 1 ]. Patients are grouped according to the age at onset, presence of a specific antibody, thymus pathology, and distribution of symptoms [ 2 ]. The majority of patients (approximately 80%) have antibodies against the nicotinic ... Myasthenia gravis (MG) is a relatively rare autoimmune disorder Refractory myasthenia gravis identifies the group of patients that have inadequate symptom control and persistent muscle weakness and fatigability despite the use of multiple immune modulatory therapies. This manuscript highlights what is currently known about refractory myasthenia gravis and underlines major knowledge gaps, drawing attention to the …Myasthenia gravis with (acute) exacerbation. G70.01 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2024 edition of ICD-10-CM G70.01 became effective on October 1, 2023. Myasthenia gravis (MG) is a rare autoimmune disease that affectsIntroduction. Myasthenia gravis is an autoimmune disease of 19 янв. 2017 г. ... ... all symptoms.8 The disease may become refra Of all patients with MG, a fraction (estimated at 10%) have disease that is refractory to treatment with conventional agents such as cholinesterase inhibitors and immunosuppressive agents (including corticosteroids, azathioprine, and cyclosporine). 7 - 9 In this article, we review the natural course of MG, various definitions of the term treatme...Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorder that causes skeletal muscle fatigable weakness and is the most common neuromuscular disorder. 1 Management of MG is based on clinical severity of symptoms, type of autoantibody involved, age, comorbidities, and the presence of thymoma. Conventional treatment may be … Myasthenia gravis (MG) is the most common disorder of neuromuscular t the impact of refractory MG on mental health and health-related quality of life. This review aims to highlight the burden of disease and unmet needs in patients with refractory MG. Keywords: burden, definition, disability, quality of life, refractory myasthenia gravis, side effects, tolerability, treatment, unmet need Conclusion. Our investigation revealed the effect [Clinical characteristics of refractory myastheniaRituximab improves clinical characteristics Abstract. Purpose: To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using the Quality of Life in Neurological Disorders (Neuro-QOL) Fatigue subscale, and to evaluate correlations between improvements in Neuro-QOL Fatigue and ...