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The effects of βCD and MβCD on the solubility of SMT were studied as follows: an excess of SMT was added to aqueous buffered solutions of pH 2.0, pH 8.0, or water containing different amounts of βCD (0–13.2 mM) or MβCD (0–105 mM for water and 0–84 mM for pH 2.0 and 8.0). The resulting suspensions were sonicated in an ultrasonic …T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies According to Higuchi and Connors’ theory, [17] the phase-solubility relationships between PD and β- and γ-CDs are classified as typical A L-type, ... according to the method reported by Higuchi and Connors (1965). ... Phase solubility techniques. Adv. Anal. Chem. Instrum., 4 (1965), pp. 117-212. View in Scopus Google Scholar3.8. Solubility Studies. The phase-solubility profiles of the three polymorphic forms of benzocaine were determined according to the method of Higuchi and Connors , and were performed by using a Thermo Scientific™ MaxQ™ 4450 Benchtop Orbital Shaker (Thermo Scientific, Waltham, MA, USA). To 25.0 mL flasks, containing 10.0 mL methanol …The phase solubility study of CDL with PSC[4]arene and PSC[6]arene were executed according to Higuchi and Connors . Phase solubility studies were accomplished at 27 °C temperature, in triplicate. Excess quantity of CDL (250 mg) was added into different conical flasks containing 150 mL aqueous solutions of PSC[4]arene and PSC[6]arene at …5. Higuchi T, Connors K. Phase-solubility techniques. Advances in Analytical Chemistry and Instrumentation, 4, 1965, 117-212 6. Renu Chadha, Anupam Saini, Poonam Arora, Somnath Chanda. Co-crystals of efavirenz with selected coformers: preparation and characterization. International Journal of Pharmacy and Pharmaceutical Sciences Vol 4, …T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesPhase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117-212. [Google Scholar] 26. Doile KM ...The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...The effect of L-arginine was investigated on complexation efficiency of β-cyclodextrin towards Epalrestat in an aqueous media through phase solubility according to Higuchi and Connors. Phase ...Phase solubility behavior was studied according to the method proposed by Higuchi and Connors ... Phase solubility techniques. Adv. Anal Chem Instrum 1965; 4: 117 ...The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …According to the phase-solubility diagram classification system that was introduced by Higuchi and Connors , linear A L-type diagrams show that the total drug solubility increases as a function of …Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying techniqueTernary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid …Dec 15, 2022 · The solubility of CUR increased linearly with increasing concentrations of β-CD, represented as an A L type phase solubility curve (Higuchi & Connors, 1965; Jiang et al., 2019). The results of ANONA of the phase solubility model were provided in Table 1. F value (409.54) was extremely significant (p value < 0.001) suggesting that the model was ... T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies Phase solubility studies were performed by the mTo establish the increase of ezetimibe water solubili 3.8. Solubility Studies. The phase-solubility profiles of the three polymorphic forms of benzocaine were determined according to the method of Higuchi and Connors , and were performed by using a Thermo Scientific™ MaxQ™ 4450 Benchtop Orbital Shaker (Thermo Scientific, Waltham, MA, USA). To 25.0 mL flasks, containing 10.0 mL methanol …T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies Phase solubility of FA/HP-β-CD complex. Aug 8, 2022 · Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ... Phase Solubility Study. Phase solubility study was carried out ac

Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added.Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this article at. ScienceOpen Bookmark. There is …ResearchGate | Find and share research Phase solubility. Compatibility of host and guest relationship was determined by Higuchi-Connors phase solubility method [16]. Excess amount of drug was added in flask containing different molar ratios of βCD mixed in distilled water. Flasks were placed in water bath (TSSWB15-USA) at 37 ± 2 °C with speed of 100 rpm for 72 h.

3.8. Solubility Studies. The phase-solubility profiles of the three polymorphic forms of benzocaine were determined according to the method of Higuchi and Connors , and were performed by using a Thermo Scientific™ MaxQ™ 4450 Benchtop Orbital Shaker (Thermo Scientific, Waltham, MA, USA). To 25.0 mL flasks, containing 10.0 mL methanol …23 Ağu 2019 ... Figure 3: Higuchi-Connors diagram showing total substrate solubility versus CD concentration. A-type diagrams relate to the water-soluble ...…

Reader Q&A - also see RECOMMENDED ARTICLES & FAQs. A phase-solubility study, where the drug (i.e. the substrate) s. Possible cause: This article reports the solubilization of the practically water insoluble dr.